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Human NRAS (G13S) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human NRAS (G13S) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0042C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human NRAS (G13S) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. NRAS (G13S) BAF3 mutant cell line is generated by stable integration of exogenous human NRAS gene harboring the G13S mutation into Ba/F3 host cells using our optimized transduction of lentiviral vectors.
Target
NRAS is a key small GTPase regulating intracellular signaling cascades such as RAF/MEK/ERK and PI3K/AKT pathways. The G13S mutation disrupts intrinsic GTPase activity, resulting in constitutive activation of downstream effectors and enhanced proliferative signaling. This mutation has been identified in various solid tumors and hematologic cancers. AcceGen offers custom-generated mutant models to facilitate oncogenic pathway research and therapeutic development. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The NRAS (G13S) BAF3 Cell Line is a valuable tool for investigating RAS-driven malignancies, studying IL-3-independent growth, and testing RAS/MAPK pathway inhibitors. It supports functional genomics, resistance mechanism analysis, and precision oncology efforts.

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