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Human NRAS (Q61H) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human NRAS (Q61H) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0048C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human NRAS (Q61H) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. NRAS (Q61H) BAF3 mutant cell line is established via stable lentiviral transduction of human NRAS containing the Q61H substitution into Ba/F3 cells.
Target
NRAS plays a pivotal role in controlling cell fate through MAPK and PI3K pathways. The Q61H mutation disrupts GTP hydrolysis, maintaining NRAS in an active conformation and supporting aberrant proliferative signaling. This hotspot mutation is enriched in melanoma and leukemia. AcceGen provides advanced mutant models to uncover oncogenic RAS signaling and resistance mechanisms. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The NRAS (Q61H) BAF3 Cell Line is ideal for functional analysis of NRAS activation, IL-3-independent proliferation, and sensitivity to RAS/MAPK pathway inhibitors. It supports translational cancer research and therapeutic target validation.

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