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Primary Cells

Human Osteocytes

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Species

Human

Cat.No

ABC-TC158L

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Primary Cells
Size/Quantity

1 vial

Cell Type

Osteocytes

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Bone Marrow

Disease

Normal

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Osteocytes

Description

Human Osteocyte Primary Cells are derived from human bone marrow tissue. Following primary culture, these cells are cryopreserved. Osteocytes are terminally differentiated cells embedded within the mineralized bone matrix. They are essential regulators of bone remodeling and mineral homeostasis. Osteocytes play critical roles in mechanosensation and signal transduction within the skeletal system. Studies have demonstrated that osteocytes are involved in the pathogenesis and progression of various bone diseases, such as osteoporosis and osteoarthritis. In vitro, these cells do not proliferate and cannot be subcultured. To maintain cellular viability and function, repeated freezing and thawing during culture should be avoided.

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Citation

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Application

  • Human osteocytes regulate bone remodeling by triggering osteoclast-mediated resorption and osteoblast-mediated formation; perform mechanosensing by detecting mechanical/fluid shear stress to regulate bone turnover; enhance stem cell osteogenesis for potential bone regeneration; secrete endocrine factors (e.g., FGF-23) to maintain mineral homeostasis and phosphate metabolism; maintain bone health by preventing osteoporosis through turnover regulation; and enable bone biology, regeneration, and disease mechanism research.

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