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Transfected Stable Cell Lines

Human PD1 (LAG3) MC38 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human PD1 (LAG3) MC38 Cell Line
Species

Human
Cat.No

ABC-X0348C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial-like
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Colon
Disease

Colon Adenocarcinoma
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

MC38

Description

Human PD1 (LAG3) MC38 Overexpression Cell Line is a genetically engineered model derived from murine MC38 colon adenocarcinoma cells based on customers’ requirement. PD1 (LAG3) MC38 overexpression cell line stably expresses human PD1 and LAG3 immune checkpoint proteins via lentiviral delivery. The dual-expressing clone is validated by qRT-PCR and maintained at low passage numbers (<P20). Target PD1 (PDCD1) and LAG3 are co-inhibitory receptors expressed on T cells and other immune subsets. Co-expression of these targets in tumor models allows the study of immune evasion and therapeutic response to checkpoint blockade. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This model co-expresses human PD-1 and LAG-3 in the murine MC38 colorectal cancer cell line, enabling the study of immune checkpoint biology in a tumor microenvironment context. It is ideal for investigating immune evasion, evaluating anti-PD-1 and anti-LAG-3 antibodies, and modeling dual-checkpoint blockade strategies. The cell line is widely applied in immuno-oncology research and syngeneic mouse model development for preclinical therapeutic testing.

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