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Human PIK3CA (H1047R) SK-BR-3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human PIK3CA (H1047R) SK-BR-3 Cell Line
Species

Human
Cat.No

ABC-X0371C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Breast
Disease

Adenocarcinoma
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

SK-BR-3

Description

Human PIK3CA (H1047R) SK-BR-3 Cell Line is a genetically engineered model derived from selected human breast cancer SK-BR-3 parental cell line based on customers’ requirement. PIK3CA (H1047R) SK-BR-3 overexpression cell line is generated by stable integration of exogenous human PIK3CA gene harboring the H1047R hotspot mutation using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
PIK3CA encodes the p110α catalytic subunit of PI3K, a central regulator of cell survival and growth. The H1047R mutation constitutively activates PI3K/AKT/mTOR signaling, contributing to oncogenesis in breast and other solid tumors. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The PIK3CA (H1047R) SK-BR-3 Overexpression Cell Line supports oncogenic signaling research and is suitable for evaluating PI3K inhibitors and resistance mechanisms in HER2+ breast cancer models.

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