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Transfected Stable Cell Lines

Human PIK3CA (P539R) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0284C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocytes
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

The human PIK3CA (P539R) BAF3 Cell Line is used to study oncogenic PIK3CA mutations influencing PI3K/AKT pathway and drug resistance in tumors.

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  • Human PIK3CA (P539R) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human PIK3CA (P539R) BAF3 Cell Line

Description

Human PIK3CA (P539R) BAF3 Cell Line is a genetically engineered model derived from murine pro-B Ba/F3 parental cells based on customers’ requirement. PIK3CA (P539R) BAF3 overexpression cell line is generated by stable integration of exogenous human PIK3CA gene with the P539R activating mutation. Lentiviral transduction is used for delivery, and cultures are maintained below passage 20. Validation is conducted by qRT-PCR.
Target
PIK3CA encodes the p110α catalytic subunit of PI3K, a central node in growth and survival pathways. The P539R mutation lies in the helical domain and enhances lipid kinase activity, contributing to oncogenesis in breast, colorectal, and endometrial cancers. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0284C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • This model enables mechanistic investigation of PI3K activation, resistance to PI3K inhibitors, and serves as a platform for screening targeted therapies in PIK3CA-driven cancers.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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