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Transfected Stable Cell Lines

Human PIK3CA_E542K NCI-H1975 Cell Line

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    1

  • 90
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human PIK3CA_E542K NCI-H1975 Cell Line
Species

Human
Cat.No

ABC-X0188C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lung
Disease

Carcinoma
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

NCI-H1975

Description

Human PIK3CA_E542K NCI-H1975 Cell Line is a human lung adenocarcinoma model derived from NCI-H1975 cells, engineered to stably express the oncogenic PIK3CA E542K mutation. Lentiviral vector integration ensures sustained expression, validated by qRT-PCR. Cells are expanded under low-passage culture (<P20). Target PIK3CA encodes the p110α catalytic subunit of PI3K. The E542K hotspot mutation in the helical domain constitutively activates PI3K/AKT signaling, promoting tumor growth and therapeutic resistance. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers' research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This model is applicable for PI3K pathway investigation, resistance profiling to PI3K inhibitors, and preclinical testing of targeted therapies in EGFR/PIK3CA-mutant contexts.

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