Human Psoriasis Peripheral Blood Mononuclear Cells

Description

Human Psoriasis Peripheral Blood Mononuclear Cells are isolated from the peripheral blood of patients with psoriasis, an immune-mediated chronic inflammatory skin disease. Peripheral blood from psoriasis patients.These cells are derived from the mononuclear cell fraction of the blood, which mainly includes lymphocytes (T cells, B cells, NK cells) and monocytes. Morphologically, PBMCs appear as small and round cells. They play a central role in the pathogenesis of psoriasis. Upregulated inflammatory cytokines IL-17 and TNF-α from activated T cellsAbnormal activation of T cells secretes inflammatory factors such as IL-17 and TNF-α, which in turn leads to excessive proliferation of keratinocytes and chronic inflammation. Central role in psoriasis pathogenesis by driving keratinocyte proliferation and maintaining chronic skin inflammation.