Human Psoriasis Peripheral Blood Mononuclear Cells

Description

Human Psoriasis Peripheral Blood Mononuclear Cells (PBMCs) are isolated from the peripheral blood of patients with psoriasis, an immune-mediated chronic inflammatory skin disease. Peripheral blood from psoriasis patients. These cells are derived from the mononuclear cell fraction of the blood, which mainly includes lymphocytes (T cells, B cells, NK cells) and monocytes. Morphologically, PBMCs appear as small and round cells. They play a central role in the pathogenesis of psoriasis. Upregulated inflammatory cytokines IL-17 and TNF-α from activated T cells. Abnormally activated T cells secretes inflammatory factors such as IL-17 and TNF-α, which in turn leads to excessive proliferation of keratinocytes and chronic inflammation. Central role in psoriasis pathogenesis by driving keratinocyte proliferation and maintaining chronic skin inflammation. In translational and clinical research, these samples support PBMC phenotyping psoriasis and comprehensive PBMC cytokine profiling to elucidate psoriasis systemic inflammation, evaluate immune modulation in psoriasis, and accelerate novel therapies involving PBMC psoriasis.