Human Pulmonary Art Sm Mus Cells-Diabetic Type II

Description

Human Pulmonary Art Sm Mus Cells-Diabetic Type II are isolated from the pulmonary artery vascular tissues of patients with type II diabetes. The cells express smooth muscle markers such as α-smooth muscle actin (α-SMA). Functionally, these cells regulate pulmonary artery vascular tension through contraction and relaxation to maintain pulmonary circulation homeostasis. Under the pathological environment of diabetes, stimuli such as hyperglycemia, insulin resistance, and advanced glycation end products (AGEs) can induce phenotypic transformation of these cells, which is manifested as weakened contractile function, enhanced proliferation and migration ability, and accompanied by extracellular matrix remodeling, promoting vascular wall thickening and fibrosis. These cells provide a platform to investigate diabetes type 2 effects on pulmonary SMCs. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.