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Primary Cells

Human Pulmonary Pericytes

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Human Pulmonary Pericytes are distributed in the microvasculature of lung tissue, key factors of regulating angiogenesis, stability, and function. Pericytes are typically characterized by a prominent nucleus with less cytoplasm around the nucleus and many protrusions parallel to the long axis of the microvessel, which taper and surround the microvascular lumen to support the lumen. […]
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Home | Primary Cells | Human Primary Cells | Respiratory System Primary Cells | Human Pulmonary Pericytes
Species

Human
Cat.No

ABC-H0044X
Quality Control

All cell lots test negative for HIV-1, HBV, HCV, mycoplasma, yeast, fungi, and other pathogens.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Pericyte
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Lung
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Pulmonary Cells
Key Features

– Backed by AcceGen advanced technology
– Cryopreserved for highest viability and plating efficiency
– Quality-guaranteed for accurate results
– Timely technical support for best experimental outcomes

Description

Human pulmonary pericytes are mesenchymal cells derived from the microvasculature of normal human lung tissue. These cells exhibit a spindle-shaped, fibroblast-like morphology and grow adherently under standard culture conditions. Typically isolated at early passage, they are non-immortalized and can only undergo limited in vitro expansion. Pulmonary pericytes play essential roles in angiogenesis, capillary integrity maintenance, vascular remodeling, and immune modulation in the lung. They respond to injury by releasing proinflammatory cytokines and regulate the PDGF-PDGFRβ signaling axis, crucial for vasculature repair. Dysregulation of these cells is associated with pulmonary fibrosis and chronic lung inflammation. The cells show a normal human karyotype, and markers such as PDGFRβ, NG2, and CD146 are expressed.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

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Application

  • Growing evidence highlights the central role for pericytes as myofibroblast precursors, contributing to the development of lung disorders such as fibrosis and asthma. Human pulmonary pericytesserve as an accessible model for studying the biology and pathophysiology of primary pericytes. Exploring the interactions between pericytes and endothelial or other pulmonary cells may offer novel insights into pulmonary circulation and the underlying mechanisms of lung disease..

Frequently Asked Questions

  • What are pulmonary pericytes?

    Pulmonary pericytes are specialized contractile cells found wrapped around the endothelial cells of capillaries and venules in the lungs. They play a crucial role in maintaining blood vessel stability, regulating blood flow, and supporting the endothelial cells.

  • What is the primary function of pulmonary pericytes?

    The primary function of pulmonary pericytes is to provide structural support to blood vessels, regulate blood-brain barrier integrity, influence blood flow, and participate in the repair and regeneration of the vasculature in the lungs.

  • Is dysfunction of pulmonary pericytes associated with the development of pulmonary diseases?

    Yes, dysfunction of pulmonary pericytes is closely related to pulmonary diseases such as pulmonary hypertension, fibrosis, and chronic obstructive pulmonary disease (COPD). Their malfunction can lead to abnormal vascular remodeling, inflammation, and tissue scarring, exacerbating the progression of these conditions.

  • How do pulmonary pericytes interact with endothelial cells?

    Pulmonary pericytes interact with endothelial cells through direct physical contact and paracrine signaling. These interactions are essential for blood vessel stability, regulation of permeability, and angiogenesis.

  • What signaling pathways are involved in pulmonary pericyte function?

    Key signaling pathways involved in pulmonary pericyte function include the PDGF (platelet-derived growth factor) pathway, TGF-β (transforming growth factor-beta) pathway, and Notch signaling. These pathways regulate pericyte proliferation, migration, and differentiation.

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