Human SLE Peripheral Blood Mononuclear Cells

Description

Human SLE Peripheral Blood Mononuclear Cells are derived from the peripheral blood of patients with systemic lupus erythematosus (a systemic autoimmune disease), including lymphocytes (T cells, B cells, NK cells), monocytes and dendritic cells, Typical mononuclear morphology with small to medium round cells; suspension growth[1-2].Peripheral blood from systemic lupus erythematosus (SLE) patients PBMCs play a core role in the pathogenesis of SLE. Their functional abnormalities include overactivation of B cells leading to autoantibody secretion, imbalanced T cell regulation, and release of proinflammatory factors (IFN-α, IL-6) [3-4]. These abnormalities are closely related to the typical characteristics of SLE, such as immune complex deposition and multi-organ damage (kidney, skin, joints). Increased expression of activation markers like CD69, CD86 on B and T cells; elevated type I interferon signature genes; high autoantibody (anti-dsDNA) producing B cells.Abnormal immune complex deposition triggers chronic inflammation and multi-organ damage typical of SLE.