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Transfected Stable Cell Lines

Human TPR (Met_H1094Y) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human TPR (Met_H1094Y) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0053C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human TPR (Met_H1094Y) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. TPR (Met_H1094Y) BAF3 mutant cell line is generated through stable lentiviral transduction of human TPR gene fused with MET sequence and carrying the H1094Y mutation.
Target
TPR-MET is a fusion oncoprotein that results from chromosomal rearrangement, leading to constitutive activation of MET kinase signaling. The H1094Y mutation further enhances kinase activity and downstream oncogenic pathways such as RAS/MAPK and PI3K/AKT. This combination promotes cellular transformation and survival. AcceGen provides stable fusion and mutant models for studying targeted therapeutic strategies. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The TPR (Met_H1094Y) BAF3 Cell Line offers a unique model for evaluating oncogenic MET fusion activity and drug response. It supports discovery of MET inhibitors, resistance studies, and mechanistic exploration of aberrant tyrosine kinase signaling.

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