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Human Type II Diabetes Peripheral Blood Mononuclear Cells

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Human Peripheral Blood Mononuclear Cells are available as positive and negative controls for T-cell monitoring in ELISPOT, ELISA, cytokine bead array, tetramer/pentamer, and flow cytometry assays. A peripheral blood mononuclear cell is defined as any blood cell with a round nucleus. These blood cells are a critical component in the immune system to fight infection […]
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Home | Primary Cells | Human Primary Cells | PBMCs | Human Type II Diabetes Peripheral Blood Mononuclear Cells
Species

Human
Cat.No

ABC-TC4265
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Mononuclear Cell
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Peripheral Blood
Disease

Type II Diabete
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Diseased Human Peripheral Blood Mononuclear Cells

Description

Human type II diabetes peripheral blood mononuclear cells (PBMCs) are immune cells obtained from donors with type II diabetes mellitus (T2DM) using a density gradient centrifugation method. PBMCs consist of a diverse population of white blood cells, mainly composed of monocytes (20%) and lymphocytes (T and B cells), alongside other lymphoid-origin cells. Notably, Human Type II Diabetes Peripheral Blood Mononuclear CellsPBMCs from T2DM patients exhibit elevated expression of the CD68 marker, while the expression of CD11b and CD163 is significantly reduced. Furthermore, mRNA levels of CD11b, CD11c, CD169, and CD163 are significantly decreased in T2DM PBMCs. For accurate gene expression analysis in PBMCs from diabetics, stable reference genes such as ACTB, PPIB, YWHAZ, and GAPDH can be employed.

 

Why choose Human Type II Diabetes Peripheral Blood Mononuclear Cells from AcceGen?

AcceGen’s Human Type II Diabetes Peripheral Blood Mononuclear Cells (PBMCs) are an ideal choice due to their high viability after thawing. These cells are sourced from donors who have undergone rigorous testing, ensuring they are negative for HIV-1 and 2, hepatitis B, and hepatitis C. Additionally, the product remains stable at -135 °C or colder for a duration of 12 months from the date of receipt, ensuring long-term usability and reliable experimental results.

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Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

  • For research use only.

  • Peripheral blood mononuclear cells (PBMCs) are widely used in experimental studies. They are isolated from peripheral blood and are often employed to assess immune responses. PBMCs have wide application in many hot topics, for example, multi-omics analysis of PBMCs based on CITE-seq data, in vitro differentiation of PBMCs into cardiomyocytes or vascular-associated cells. Our products are ideal for establishing an in vitro PBMC differentiation system that allows you to combine molecular and cytological approaches to study the differentiation mechanisms of PBMCs.

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