Human Type II Diabetes Peripheral Blood Mononuclear Cells (PBMCs) are immune cells isolated from the peripheral blood of patients with Type II Diabetes Mellitus (T2DM) using density gradient centrifugation. These cells consist mainly of monocytes (20%) and lymphocytes (T and B cells). PBMCs from T2DM patients exhibit elevated CD68 expression and reduced CD11b and CD163 expression, with corresponding decreases in the mRNA levels of CD11b, CD11c, CD169, and CD163. In culture, PBMCs are grown in RPMI-1640 medium supplemented with 10% fetal bovine serum and are known to have limited in vitro proliferation. These cells do not exhibit tumorigenic or metastatic behavior. They serve as an important model for studying immune system alterations in T2DM. PBMCs from T2DM patients also show a higher prevalence of Epstein-Barr virus (EBV) infection, which may contribute to immune dysfunction.
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