Human Uterine Cancer Peripheral Blood Mononuclear Cells

Description

Human Uterine Cancer Peripheral Blood Mononuclear Cells (PBMCs) are isolated from peripheral blood of patients with endometrial carcinoma, the most common gynecologic malignancy in developed countries. These human-derived PBMCs contain lymphocytes (T cells, B cells, NK cells) and monocytes that demonstrate cancer-specific immune alterations, including increased Treg population (CD4⁺CD25⁺FoxP3⁺) and exhausted PD-1⁺CD8⁺ T cells characteristic of tumor-mediated immunosuppression. PBMCs exhibit typically mononuclear morphology with intact surface markers and maintain functional cytokine production in response to tumor antigens. They are particularly valuable for studying hormone-driven (estrogen/progesterone receptor-related) immune modulation in endometrial cancer, which shows distinct molecular subtypes with varying immunogenicity. These PBMCs are essential for evaluating adaptive immunity in uterine cancer, enabling detailed pbmc profiling uterine cancer and providing insights into the uterine carcinoma immune response.