Human ZRSR2 Knockout Cell Line

Description

ZRSR2 Knockout Cell Line is a genetically engineered model derived from different host cell lines based on customers’ requirement. Among various options, HEK293, a human embryonic kidney cell line, is one of the most commonly selected parental cell line. ZRSR2 knockout line is usually generated via CRISPR/Cas9-mediated gene editing. The edited cells are maintained at low passage numbers (<P20). Knockout clone is validated either at gene level or protein level by PCR, Sanger Sequencing or Western Blot. Target The ZRSR2 gene encodes a zinc finger protein involved in the splicing of U12-type introns, critical for gene expression regulation. Mutations or loss of ZRSR2 are frequently found in myelodysplastic syndromes (MDS) and other hematologic malignancies, leading to defective splicing and impaired hematopoiesis.

Application

• For research use only
  

• ZRSR2 Knockout Cell Line serves as a model for studying U12-type intron splicing, hematologic malignancy pathogenesis, and potential therapeutic strategies targeting splicing defects in MDS.