Immortalized Human Fibroblast-Like Synoviocyte

Description

Immortalized Human Fibroblast-Like Synoviocytes are genetically modified cells derived from human synovial tissue, engineered for extended proliferative capacity while preserving native morphology and function. These spindle-shaped, adherent synoviocytes play a crucial role in rheumatoid arthritis (RA) pathogenesis, exhibiting a hyperproliferative, invasive phenotype. These cells exhibit fibroblast-like characteristics, expressing typical markers including vimentin and fibronectin, while maintaining responsiveness to proinflammatory cytokines. Transcriptomic profiles show elevated expression of matrix metalloproteinases (MMPs) and inflammatory mediators. With a stable karyotype and lack of tumorigenicity in vivo, immortalized FLS provide a robust and reproducible in vitro model for studying synovial inflammation, joint destruction, and therapeutic interventions in chronic inflammatory arthritis-findings consistent with immortalized reviews focusing on synovial biology research.

Application

• Immortalized Human Fibroblast-Like Synoviocytes provide an effective in vitro model for studying synovial cell biology and the pathogenesis of joint diseases. They support research into synovial tissue organization and may serve as therapeutic targets. These cells are also employed in high-throughput and high-content screening models, accelerating the discovery and development of treatments for inflammatory and degenerative joint disorders.