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Immortalized Cell Lines

Immortalized Human Microglia

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Immortalized Human Microglia (SV40 cell line) is derived from Primary Human Microglia Cells (>99% purity) and have maintained microglial specific markers such as Iba1, CD68, TREM2 and CD11b. These cells are suitable for studies of human microglia in health and disease.
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Home | Immortalized Cell Lines | Immortalized Human Microglia
Species

Human
Cat.No

ABI-TC4171
Quality Control

All cell lots test negative for HIV-1, HBV, HCV, mycoplasma, yeast, fungi, and other pathogens.
Product Category Immortalized Cell Lines
Size/Quantity

1 vial
Cell Type

Microglia
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Brain
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Immortalized Cell Line
Immortalization Method

Lenti‐SV40 Lentivirus
Key Features

– Backed by AcceGen advanced technology

– Cryopreserved for highest viability and plating efficiency

– Quality-guaranteed for accurate results

– Timely technical support for best experimental outcomes

Description

Immortalized Human Microglia (SV40) are derived from normal adult brain tissue and immortalized via SV40 large T antigen lentiviral transduction, granting them extended proliferation. They display a typical ramified morphology, express markers like Iba1, CD68, TREM2, and CD11b, and exhibits adherent culture properties.. Functionally, they engage in immune surveillance, synaptic pruning, and inflammation. When stimulated by LPS or β-amyloid, they release IL-1β, TNF-α, and nitric oxide. They are non-tumorigenic in vivo. These cells are cryopreserved at early passages. They’re ideal for studying neuroinflammation, neurodegeneration, and CNS-targeted drugs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Imm, J.L., 2020. Methylomic variation induced by LPS exposure in a microglial cell line: Genetics/omics and systems biology. Alzheimer’s & Dementia, 16, p.e042571.
Imm, J., 2020. Exploring the Epigenome of Neurons and Glia in Vitro to Determine their Utility as a Model for Alzheimer’s Disease.
Munawara, U., Catanzaro, M., Xu, W., Tan, C., Hirokawa, K., Bosco, N., Dumoulin, D., Khalil, A., Larbi, A., Lévesque, S. and Ramassamy, C., 2021. Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer’s disease. Immunity & Ageing, 18(1), pp.1-25.

Application

  • Microglia research has long been constrained by the availability of primary human sources. Immortalized Human Microglia (SV40 cell line) offers a consistent and accessible model that allows the establishment of in vitro models for studying the physiological and pathological properties of microglia cells. They can also be used to study neuron-microglia interactions and mechanisms underlying neurodegenerative and neuroinflammatory conditions

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High Viability
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