For research use only
| Cat No. | ABC-TC0524 |
| Product Type | Human Myeloma Cell Lines |
| Cell Type | Lymphocyte-like |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Pleural Effusion |
| Product Code | KMS11; kms11; kms 11 |
Human Myeloma KMS-11 secrete IgG κ, carry FGFR3 mutation (p.Tyr373Cys),adherent and suspension growth,high tumor markers, no tumor formation in nude mice.
KMS-11 is a human multiple myeloma (MM) cell line derived from the peripheral blood of a 66-year-old Japanese female patient with relapsed myeloma. These suspension cells display lymphoblastoid morphology and are classified as malignant plasma cells. KMS-11 carries a t(4;14)(p16. 3;q32. 3) chromosomal translocation, which leads to the FGFR3 gene mutation (p. Tyr373Cys) and high expression of MMSET genes—hallmark features in a subset of high-risk myeloma. The cells exhibit an abnormal karyotype with complex chromosomal rearrangements and are tumorigenic in immunocompromised mice, making them a suitable model for studying disease progression and drug resistance. These cells serve as a valuable tool for studying MM pathogenesis and novel therapeutic strategies.
| Product Code | KMS11; kms11; kms 11 |
| Species | Human |
| Cat.No | ABC-TC0524 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Lymphocyte-like |
| Growth Mode | Suspension |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Pleural Effusion |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Myeloma Cell Lines |
KMS-11 is widely used in multiple myeloma research to evaluate anti-myeloma drugs, study mechanisms of drug resistance, and dissect signaling pathways driving plasma cell malignancy. Its ability to engraft and form tumors in xenograft models makes it valuable for in vivo efficacy testing of experimental agents. KMS-11 also serves as a model to investigate tumor-microenvironment interactions in the bone marrow niche.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
