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KMS-11 | ||||
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| Product Name | KMS-11 | |||
| Price | Get Quote | |||
| Product Code | KMS11; kms11; kms 11 | |||
| Cat.No | ABC-TC0524 | Species | Human | |
| Size/Quantity | 1 vial | Biosafety Level | 1 | |
| Shipping Info | Dry Ice | Storage | Liquid Nitrogen | |
| Description | KMS-11 was established from the patients with multiple myeloma. KMS-11 can stably grow in RPMI1640 medium with 10% FBS. KMS-11 can produce immunoglobulin kappa (IgG kappa) into the culture medium. KMS-11 presents positive reaction with a monoclonal plasma cell antibody (PCA-1). KMS-11 is in a later stage of B-cell differentiation, though this cell lines has no feature of Epstein-Barr virus nuclear antigen and abnormal karyotypes. Caused by a chromosomal translocation, the fibroblast growth factor receptor 3 (FGFR3) is overexpressed in KMS-11 cell line.
Why Choose KMS-11 from AcceGen? Accegen supports KMS-11 cell line with the highest viability and plating efficiency, using the special and advanced technology. All the production and tests of quality control are operated in our world-class laboratory by the professional technicians. | |||
| Source Organ | Pleural Effusion | |||
| Recommended Medium And Supplement | RPMI 1640 + 10% FBS | |||
| Citation Guide | When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID). | |||
| Application | FOR RESEARCH USE ONLY From the estimation by American Cancer Society, there will be 35730 new cases of multiple myeloma and 12590 deaths caused by multiple myeloma in the US for 2023. KMS-11 can be used in drawing signaling pathways of cell proliferation in the pathophysiology of multiple myeloma and determing inhibitors for human myeloma cell growth and survival. For example, Interleukin-6 (IL-6) was identified as one of the most important growth factors for myeloma cells, and it induced growth enhancement in KMS-11 cell lines, accompanied by down-regulation of protein kinase C (PKC) activity. JAK inhibitor, which can affect the IL-6/JAK signal transduction, induced cell death of the KMS-11 cells and inhibited tumor growth in a KMS-11 xenograft mouse model. For drug development, ginseng was observed as a candidate for the treatment of myeloma. IH901, a derivative of ginseng, triggered a serious biochemical activities, including the cleavage of poly (ADP-ribose) polymerase (PARP), internucleosomal DNA fragmentation, the activation of caspase-3, the down-regulation of FGFR3, the inhibition of ERK activity, and the apoptosis in KMS-11 cell line. | |||
| Growth Conditions | 37 ℃, 5% CO2 | |||
| Cell Type | Lymphocyte-like | |||
| Growth Mode | Suspension | |||
| Product Type | Human Myeloma Cell Lines | |||
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