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| Product Code | KMS 12 BM; KMS-12BM; KMS12-BM; KMS12BM; KMS-12; KMS12 |
| Species | Human |
| Cat.No | ABL-TC0346 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Lymphocyte-like |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Bone Marrow |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Myeloma Cell Lines |
KMS-12-BM is a human myeloma cell line derived from the bone marrow of a 64-year-old female with non-secretory multiple myeloma. These lymphocyte-like cells grow in suspension and often form small clusters, useful for studying plasma cell aggregation. Cytogenetic analysis shows a t(11;14)(q13;q32) translocation, associated with cyclin D1 (CCND1) dysregulation. They represent the plasmacytoid B-cell stage and are negative for surface and cytoplasmic immunoglobulins. The cells express CD20, CD38, and PCA-1, and lack EBNA, indicating no EBV involvement. Free from mycoplasma, bacteria, fungi, HIV-1/2, HBV, and HCV, they grow in RPMI-1640 with 10% FBS and maintain high viability under strict quality control. KMS-12-BM serves as a reliable model for plasma cell biology, multiple myeloma pathogenesis, biomarker discovery, and drug screening.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
KMS-12-BM cells have emerged as a important model in multiple myeloma and plasma cell biology research. These cells provide a reliable platform for investigating the intricacies of the disease, allowing researchers to delve into its underlying molecular mechanisms. Moreover, KMS-12-BM cells enable investigation to explore the proteome and detect possible biomarkers that could aid in diagnosis and prognosis. They can also be utilized to analyze transcriptomic correlation, serving as a representative model for patient tumors and shedding light on the molecular factors influencing disease progression. Additionally, these cells are critical for in drug screening studies, offering insights into drug sensitivity and supporting the prediction of therapeutic outcomes.
