For research use only
| Cat No. | ABL-TC0346 |
| Product Type | Human Myeloma Cell Lines |
| Cell Type | Lymphocyte-like |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Bone Marrow |
| Product Code | KMS 12 BM; KMS-12BM; KMS12-BM; KMS12BM; KMS-12; KMS12 |
KMS-12-BM supports myeloma biology research, late-stage B-cell differentiation studies, and therapeutic drug evaluation in hematologic malignancy.
KMS-12-BM is a human multiple myeloma (MM) cell line derived from the bone marrow of a 64-year-old female with non-secretory MM. These cells originate from malignant plasma cells, exhibit lymphocyte-like morphology, grow in suspension and often spontaneously form clusters, useful for studying plasma cell aggregation. KMS-12-BM carries a near-tetraploid karyotype with multiple chromosomal abnormalities, including translocations involving the immunoglobulin heavy chain (IGH) locus. This cell line is notable for its expression of CD38, CD138, and CD56, and its secretion of immunoglobulin G (IgG) with kappa light chains. The cells are moderately tumorigenic in immunodeficient mice, making them suitable for both in vitro and in vivo modeling of disease.
| Product Code | KMS 12 BM; KMS-12BM; KMS12-BM; KMS12BM; KMS-12; KMS12 |
| Species | Human |
| Cat.No | ABL-TC0346 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Lymphocyte-like |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Bone Marrow |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Myeloma Cell Lines |
KMS-12-BM cells are a valuable model for multiple myeloma and plasma cell biology, facilitating investigation of disease-specific molecular mechanisms. They support proteomic analyses to identify diagnostic and prognostic biomarkers and enable transcriptomic correlation with patient tumors to elucidate factors driving disease progression. Additionally, KMS-12-BM cells are instrumental in drug screening, providing insights into drug sensitivity and aiding therapeutic outcome prediction.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
