For research use only
| Cat No. | ABC-TC0575 |
| Product Type | Rat Fibroblas Lymphocytes Cell Lines |
| Species | Rat |
| Growth Conditions | 37 ℃, 5% CO2 |
| Product Code | L6-H2 |
L6-H2 rat skeletal muscle subclone shows fibroblast-like morphology, no myotubes, proliferates in soft agar, used for muscle and cell growth studies.
L6-H2 is a spontaneously transformed, non‑myogenic subclone derived from the L6 rat skeletal muscle myoblast line. Originating from newborn male Rattus norvegicus thigh tissue, it exhibits predominantly fibroblast‑like and rounded morphology, growing as a loosely adherent monolayer and lacking myotube fusion capabilities. L6‑H2 can form colonies in soft agar, indicating anchorage‑independent growth and tumor‑like behavior. Unlike their myogenic counterparts, L6-H2 cells do not form myotubes. Gene expression studies demonstrated functional vasopressin signaling transduction, shown by arginine vasopressin–induced cAMP responses, supporting second‑messenger pathway integrity. This line offers a defined transformed myoblast‑derived model for studying transformation, signaling dynamics, and cell adhesion alterations in rodent systems.
| Product Code | L6-H2 |
| Species | Rat |
| Cat.No | ABC-TC0575 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Rat Fibroblas Lymphocytes Cell Lines |
L6-H2 cells serve as a valuable tool in the myogenic research, primarily functioning as a negative control in studies involving the L6 cell line and its various subclones. They are instrumental in elucidating the characteristics of myogenic differentiation by providing a baseline for receptor expression, chemical stimulation, and signal transduction studies. By contrasting the behavior of L6-H2 cells with myogenic variants, researchers can gain critical insights into the mechanisms govern muscle cell differentiation, deepening our understanding of this intricate process.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
