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Tumor Cell Lines

LS-180

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Human Caucasian colon adenocarcinoma. Derived from a 58 year old female Caucasian with Dukes type B adenocarcinoma of the colon. The cells secrete CEA and mucin and are tumorigenic in nude mice. LS174T was derived from the same patient.
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Product Code

LS-180; LS 180

Species

Human

Cat.No

ABC-TC0605

Product Category Tumor Cell Lines
Size/Quantity

1 vial

Cell Type

Epithelial

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Colon

Disease

Colorectal Adenocarinoma

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Human Colon Cancer Cell Lines

Description

LS-180LS-180 is a human epithelial colorectal adenocarcinoma cell line that was originally isolated and established from the large intestine and colon tissue of a 58-year-old white female patient with colon adenocarcinoma (Dukes type B adenocarcinoma). JHH-7 is a goblet cell that exhibits epithelial-like morphology and adherent culture properties. The stemline karyotype of LS-180 cells is 45, t(X;5) (q12;q31) are likely occurring translocation; 2.2% of cells were tetraploid. LS-180 can express a higher level of CEA than other human colorectal adenocarcinoma cell strains, making it an ideal candidate for gastrointestinal tract research.

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Citation

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Application

  • LS-180 cell line serves as a valuable resource in the investigation of intestinal transporter regulation. Additionally, it constitutes a strong model for conducting mechanistic studies on AHR-regulated CYP1A2 expression. Moreover, LS-180 is recognized as an exceptional tool for studying the pregnane X receptor. Its multiple applications make LS-180 a crucial asset in advancing research in these specific areas of interest.

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