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Primary Cells

Mouse Colonic Fibroblasts

  • BSL

    1

  • 38
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Home | Primary Cells | Animal Primary Cells | Mouse Colonic Fibroblasts
Species

Mouse
Cat.No

ABC-TC144W
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Fibroblast
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Colon
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Colonic Cells

Description

Mouse Colonic Fibroblasts (MCFs) are primary cells isolated from the colon tissue of adult mice, typically C57BL/6 strain. These cells exhibit a spindle-shaped morphology and express α-smooth muscle actin (α-SMA), characteristic of myofibroblasts. MCFs play a crucial role in extracellular matrix (ECM) production and remodeling, contributing to tissue homeostasis and repair. They are involved in the pathogenesis of various gastrointestinal disorders, including inflammatory bowel disease (IBD) and colorectal cancer. MCFs can be cultured and expanded in vitro for several passages, maintaining their proliferative capacity and functional properties. They serve as valuable models for studying fibroblast biology, fibrosis, and the molecular mechanisms underlying intestinal diseases.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only.

  • Mouse Colonic Fibroblasts (MCFs) are utilized to investigate ECM remodeling and fibrosis in gastrointestinal research. They are employed in studies examining the role of fibroblasts in inflammation and tissue repair processes. MCFs serve as models to explore the molecular mechanisms underlying gastrointestinal disorders, including IBD and colorectal cancer. Additionally, they are used to assess the effects of various stimuli on fibroblast activation and function, providing insights into therapeutic strategies for managing fibrotic diseases.

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