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Mouse Hepatic Stellate Cells

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Mouse Hepatic Stellate Cells (MHSteC) are isolated from Swiss mice. MHSteC are cryopreserved immediately after purification and delivered frozen (passage "0"). MHSteC is not recommend for expanding or long term cultures.
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Home | Primary Cells | Animal Primary Cells | Mouse Primary cells | Mouse Hepatic Stellate Cells
Product Code

MHSteC
Species

Mouse
Cat.No

ABC-TC3927
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Stellate Cell
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Liver
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Mouse Primary Cells

Description

Mouse Hepatic Stellate Cells (MHSC) are liver-specific mesenchymal cells derived from mouse liver, constituting 5-8% of total liver cells. Integral to liver homeostasis, maintenance, and regeneration, they excel at retinol metabolism. While quiescent in health, they harbor ample vitamin A lipid droplets, a major systemic reserve. However, in response to liver injury, MHSCs transition into an activated state marked by proliferation, Mouse Hepatic Stellate Cellscontractility, and chemotaxis. This activation contributes to liver fibrosis, underpinning ailments like hepatitis B and C, fatty liver disease, and diabetes. Consequently, understanding MHSCs holds pivotal insights into treating chronic liver diseases and their associated complications, including cirrhosis.

 

Why choose Mouse Hepatic Stellate Cells from AcceGen?

Mouse Hepatic Stellate Cells from AcceGen are cryopreserved at passage one, ensuring cell viability upon delivery. They have been rigorously characterized through immunofluorescence targeting desmin and/or α-actin, ensuring their authenticity. Importantly, they have been screened and found negative for mycoplasma, bacteria, yeast, and fungi, ensuring their purity. AcceGen provides the assurance of successful culture continuation under the recommended conditions, making them a dependable choice for your research endeavors.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

  • FOR RESEARCH USE ONLY

  • Mouse Hepatic Stellate Cells offer a robust model system for delving into various facets of liver metabolism and pathophysiology. Their application spans diverse cell-based assays, including toxicity assessment, drug screening, and metabolic studies. They emerge as a crucial resource in the study of liver fibrosis, offering insights that could drive innovative therapeutic strategies for hepatic fibrosis treatment, ultimately aiming to enhance patient outcomes and mitigate the impact of chronic liver injury.

Frequently Asked Questions

  • What role do Mouse Hepatic Stellate Cells play in liver disease progression?

    These cells become activated during liver injury, contributing to fibrosis and scar tissue formation.

  • Can Mouse Hepatic Stellate Cells revert to a quiescent state after activation?

    In some cases, with appropriate signals, they can return to a less active, quiescent state, though this is limited.

  • How do Mouse Hepatic Stellate Cells interact with other liver cell types?

    They interact closely with hepatocytes and immune cells, influencing inflammation and tissue remodeling.

  • What signaling pathways are crucial for the activation of Mouse Hepatic Stellate Cells?

    Key pathways include TGF-β, PDGF, and Hedgehog signaling, which drive the activation and proliferation of these cells.

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