Mouse Hepatic Stellate Cells (MHSCs) are primary mesenchymal cells isolated from mouse liver tissue. Primary MHSCs demonstrate limited proliferative capacity and cryopreserved immediately after isolation. These cells reside in the perisinusoidal space of Disse and account for 5–8% of hepatic cells. These cells derived from bone marrow precursors and store up to 80% of the total body vitamin A. Upon liver injury or stress, MHSCs transition into activated myofibroblasts, characterized by increased proliferation and extracellular matrix (ECM) secretion, driving fibrotic responses in conditions like non-alcoholic steatohepatitis and toxin-induced cirrhosis. Primary MHSCs retain physiological vitamin A storage and ECM remodeling functions, making them ideal for modeling early fibrotic pathways.
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