+1 862-686-2696
Featured Products
Primary Cells
Immortalized Cell Lines
Stem Cells
Tumor Cell Lines
Transfected Stable Cell Lines
Exosomes
MicroRNA Agomir/Antagomir
Cell Culture Media, kits & Reagents
Explore Products
Cell
Cell
MicroRNA
MicroRNA
Test and Analysis
Test and Analysis
Primary Cells

Mouse Hepatic Stellate Cells

  • For research use only

Cat No.

ABC-TC3927
Product Type

Mouse Primary Cells
Cell Type

Stellate Cell
Species

Mouse
Growth Conditions

37 ℃, 5% CO2
Source Organ

Liver
Disease

Normal
Storage

Liquid Nitrogen

Mouse Hepatic Stellate Cells reside in liver, store vitamin A, and upon activation drive fibrosis via ECM secretion; ideal for liver injury modeling.

Product Image
  • Mouse Hepatic Stellate Cells
Get a Quote
Home | Primary Cells | Animal Primary Cells | Mouse Primary cells | Mouse Hepatic Stellate Cells

Description

Mouse Hepatic Stellate Cells (MHSCs) are primary mesenchymal cells isolated from mouse liver tissue, specifically from the perisinusoidal space of Disse. Primary MHSCs demonstrate limited proliferative capacity and cryopreserved immediately after isolation. These mesenchymal cells exhibit star-shaped morphology when quiescent and transition to a myofibroblast-like shape upon activation. MHSCs are critical regulators of liver fibrosis, vitamin A storage, and extracellular matrix remodeling. They express markers such as desmin, glial fibrillary acidic protein (GFAP), α-smooth muscle actin (α-SMA), and collagen type I upon activation. Upon liver injury or stress, MHSCs transition into activated myofibroblasts, characterized by increased proliferation and extracellular matrix (ECM) secretion, driving fibrotic responses in conditions like non-alcoholic steatohepatitis and toxin-induced cirrhosis. Their activation is also associated with pro-inflammatory and pro-fibrogenic gene expression, making them an essential model for studying liver injury, repair, and fibrotic progression.

Product Code

MHSteC
Species

Mouse
Cat.No

ABC-TC3927
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Stellate Cell
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Liver
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Mouse Primary Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Mouse Hepatic Stellate Cells offer a robust model system for delving into various facets of liver metabolism and pathophysiology. Their application spans diverse cell-based assays, including toxicity assessment, drug screening, and metabolic studies. They emerge as a crucial resource in the study of liver fibrosis, offering insights that could drive innovative therapeutic strategies for hepatic fibrosis treatment, ultimately aiming to enhance patient outcomes and mitigate the impact of chronic liver injury.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • What role do Mouse Hepatic Stellate Cells play in liver disease progression?

    These cells become activated during liver injury, contributing to fibrosis and scar tissue formation.

  • Can Mouse Hepatic Stellate Cells revert to a quiescent state after activation?

    In some cases, with appropriate signals, they can return to a less active, quiescent state, though this is limited.

  • How do Mouse Hepatic Stellate Cells interact with other liver cell types?

    They interact closely with hepatocytes and immune cells, influencing inflammation and tissue remodeling.

  • What signaling pathways are crucial for the activation of Mouse Hepatic Stellate Cells?

    Key pathways include TGF-β, PDGF, and Hedgehog signaling, which drive the activation and proliferation of these cells.

  • Online Inquiry
  • Product Reviews

Inquiring Mouse Hepatic Stellate Cells

We know how valuable your research is to you, but are you wondering what you can expect to pay for quick accurate results every time? Fill out a request in the form below and we’ll get back to you within 24 hours with a quote.
High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

Tags

Let's Advance Life Science Research Together

Contact Us
AcceGen Scroll Top Button