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Primary Cells

Mouse Lymphatic Endothelial Cells

  • For research use only

Cat No.

ABC-TC3932
Product Type

Mouse Primary Cells
Cell Type

Endothelial
Species

Mouse
Growth Conditions

37 ℃, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

Mouse Lymphatic Endothelial Cells (MLECs) have cobblestone morphology, regulate immunity and lymphatic function, express CD31 and LYVE-1, limited passages.

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  • Mouse Lymphatic Endothelial Cells
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Description

Mouse Lymphatic Endothelial Cells (MLECs) are primary cells isolated from healthy murine lymphatic tissues. These cells exhibit a cobblestone-like or oak-leaf morphology and display adherent growth properties. These cells retain key physiological functions including maintaining fluid and protein homeostasis, regulating immune responses, and facilitating lymphocyte recirculation. They are involved in various pathological processes like lymphedema, lymphangitis, and tumor metastasis, largely due to their role in lymphatic remodeling and immune modulation. MLECs express lymphatic-specific markers, including CD31 and LYVE-1. As primary cells, MLECs have limited proliferative capacity and require optimized culture conditions to preserve functionality.

Species

Mouse
Cat.No

ABC-TC3932
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Endothelial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Mouse Primary Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • MLECs are widely employed in studies of lymphatic vessel biology under both physiological and pathological conditions. These cells serve as a critical in vitro model for investigating lymphangiogenesis, immune cell trafficking, and molecular transport mechanisms, particularly in cancer metastasis and chronic inflammatory disorders like lymphedema. Researchers employ MLECs to model tumor-induced lymphatic remodeling, to screen anti-metastatic drugs targeting VEGF-C/VEGFR-3 signaling, and to assess endothelial permeability in infection or autoimmune settings.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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