Murine Endothelial Cells

Description

Murine Endothelial Cells are primary cells derived from mouse vascular tissues and cryopreserved after initial culture. They exhibit characteristic cobblestone morphology and form adherent, confluent monolayers in vitro, representing fundamental features of mouse endothelial cell biology rather than immortalized mouse endothelial cell lines. These cells express endothelial-specific markers including CD31, VE-cadherin, and von Willebrand factor (vWF), reflecting their role in vascular barrier integrity, mouse endothelial permeability, and vascular homeostasis. Functionally, murine endothelial cells participate in angiogenesis, inflammatory signaling, and regulation of vascular tone, making them well suited for studies of murine endothelium inflammation and immune–endothelial interactions mediated by key endothelial cell signaling pathways. Owing to their species-specific origin and preserved endothelial phenotype, murine endothelial cells serve as a valuable in vitro model for in vivo–relevant cardiovascular research, including vascular disease mechanisms, endothelial dysfunction, and therapeutic screening. To maintain optimal viability and functional consistency, repeated freeze–thaw cycles should be avoided.