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Tumor Cell Lines

OE33

  • For research use only

Cat No.

ABC-TC510S

Product Type

Human Esophageal Cancer Cell Lines

Cell Type

Epithelial

Species

Human

Growth Conditions

37 ℃, 5% CO2

Source Organ

Esophagus

Disease

Esophageal Cancer

Product Code

OE-33; JROECL 33; JROECL33; OEC33

OE33 cells, from esophageal adenocarcinoma, express MHC I, ICAM-1, cytokeratins, and are tumorigenic, modeling Barrett’s metaplasia progression.

Product Image

Description

Brightfield micrograph of OE33, showing adherent growth, 4X magnification.
OE33 is a human esophageal adenocarcinoma cell line derived from the lower esophageal adenocarcinoma of a 73-year-old Caucasian female diagnosed with poorly differentiated adenocarcinoma associated with Barrett’s metaplasia. The tumor was classified as pathological stage IIA (UICC). This epithelial-like cell line exhibits adherent growth properties, with a doubling time of approximately 30-33 hours. OE33 expresseses major histocompatibility complex (MHC) class I antigens (HLA-A/B/C), intercellular adhesion molecule 1 (ICAM-1), and various epithelial cytokeratins including CK7, CK8, CK18, and CK19, while CK17 is not expressed. OE33 is tumorigenic in nude mice. Its origin from Barrett’s esophagus makes OE33 a good model for studying metaplasia-to-adenocarcinoma progression.
Product Code

OE-33; JROECL 33; JROECL33; OEC33

Species

Human

Cat.No

ABC-TC510S

Product Category Tumor Cell Lines
Size/Quantity

1 vial

Cell Type

Epithelial

Growth Mode

Adherent

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Esophagus

Disease

Esophageal Cancer

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Human Esophageal Cancer Cell Lines

Application

  • OE33 is a valuable in vitro model for investigating the molecular biology of esophageal adenocarcinoma, including tumor progression, immune response, and drug resistance. It is widely used in xenograft models for preclinical evaluation of chemotherapeutic agents such as cisplatin and 5-Fluorouracil, as well as for testing targeted therapies. OE33 is employed to investigate epithelial-mesenchymal transition (EMT) markers, cytokine signaling within tumor microenvironments, and oncogenic pathways involving HER2/EGFR alterations. Its relevance to Barrett’s-associated adenocarcinoma progression further enhances its utility in translational cancer research.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Inquiring OE33

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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