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| Product Code | OE-33; JROECL 33; JROECL33; OEC33 |
| Species | Human |
| Cat.No | ABC-TC510S |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Esophagus |
| Disease | Esophageal Cancer |
| Storage | Liquid Nitrogen |
| Product Type | Human Esophageal Cancer Cell Lines |
OE33 is a human esophageal adenocarcinoma cell line derived from the lower esophageal adenocarcinoma of a 73-year-old Caucasian female diagnosed with poorly differentiated adenocarcinoma associated with Barrett’s metaplasia. The tumor was classified as pathological stage IIA (UICC). This epithelial-like cell line exhibits adherent growth properties, with a doubling time of approximately 30-33 hours. OE33 expresseses major histocompatibility complex (MHC) class I antigens (HLA-A/B/C), intercellular adhesion molecule 1 (ICAM-1), and various epithelial cytokeratins including CK7, CK8, CK18, and CK19, while CK17 is not expressed. OE33 is tumorigenic in nude mice. Its origin from Barrett’s esophagus makes OE33 a good model for studying metaplasia-to-adenocarcinoma progression.
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OE33 is a valuable in vitro model for investigating the molecular biology of esophageal adenocarcinoma, including tumor progression, immune response, and drug resistance. It is widely used in xenograft models for preclinical evaluation of chemotherapeutic agents such as cisplatin and 5-Fluorouracil, as well as for testing targeted therapies. OE33 is employed to investigate epithelial-mesenchymal transition (EMT) markers, cytokine signaling within tumor microenvironments, and oncogenic pathways involving HER2/EGFR alterations. Its relevance to Barrett’s-associated adenocarcinoma progression further enhances its utility in translational cancer research.
