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Tumor Cell Lines

PC-3

  • For research use only

Cat No.

ABC-TC0903

Product Type

Human Prostate Cancer Cell Lines

Cell Type

Epithelial

Species

Human

Growth Conditions

37 ℃, 5% CO2

Source Organ

Prostate

Product Code

PC3; PC.3

PC-3 is a human prostate cancer cell line used for bone metastasis modeling, androgen-independent signaling, and prostate tumor drug sensitivity testing.

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Description

PC-3
PC-3 is a human prostate adenocarcinoma cell line originally derived from a bone metastasis in a 62-year-old Caucasian male with advanced prostate cancer. These cells exhibit epithelial-like morphology with irregular polygonal appearance and adherent culture properties. PC-3 has a highly aneuploid karyotype profile, with chromosomal counts ranging from 58 to 64, falling within the hypertriploid range. The cell line harbors common genetic alterations, including TP53 mutations and PTEN deletion. PC-3 is characterized by the absence of androgen receptor (AR) expression and low prostate-specific antigen (PSA) levels. The cell line is tumorigenic when implanted in SCID mice.
Product Code

PC3; PC.3

Species

Human

Cat.No

ABC-TC0903

Product Category Tumor Cell Lines
Size/Quantity

1 vial

Cell Type

Epithelial

Growth Mode

Adherent

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Prostate

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Human Prostate Cancer Cell Lines

Application

  • PC-3The PC-3 cell line is an essential model in prostate cancer research, allowing in-depth investigation into molecular and biochemical pathways involved in advanced-stage prostate cancer. It is widely used to evaluate responses to chemotherapeutic agents and explore mechanisms of drug resistance. Beyond this, PC-3 cells are commonly employed in virology studies particularly in understanding how viral infections interact with immune-related pathwasy in mammalian cells. Their compatibility with transfection techniques also makes them a reliable host for genetic and molecular biology studies. PC-3 cells are particularly valuable for modeling tumor microenvironments and assessing the therapeutic potential of experimental drugs and treatment strategies.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Saranyutanon S, Deshmukh SK, Dasgupta S, Pai S, Singh S, Singh AP. Cellular and Molecular Progression of Prostate Cancer: Models for Basic and Preclinical Research. Cancers (Basel). 2020;12(9):2651. Published 2020 Sep 17. doi:10.3390/cancers12092651

Inquiring PC-3

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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