For research use only
| Cat No. | ABC-TC0903 |
| Product Type | Human Prostate Cancer Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Prostate |
| Product Code | PC3; PC.3 |
PC-3 is a human prostate cancer cell line used for bone metastasis modeling, androgen-independent signaling, and prostate tumor drug sensitivity testing.
PC-3 is a human prostate adenocarcinoma cell line originally established from a bone metastasis of a 62-year-old Caucasian male with advanced prostate cancer. The cells exhibit irregular polygonal epithelial morphology and grow adherently in monolayer culture. PC-3 has a highly aneuploid karyotype, with a modal number of 62, placing it within the near-triploid range. This cell line harbors several characteristic genetic alterations, including mutations in TP53 and deletion of PTEN. PC-3 is androgen-independent, lacks androgen receptor (AR) expression, produces minimal prostate-specific antigen (PSA), and demonstrates low acid phosphatase and 5-alpha reductase activities. This line is tumorigenic when implanted into SCID mice, making it a valuable model for studying androgen-independent prostate cancer progression and metastasis.
| Product Code | PC3; PC.3 |
| Species | Human |
| Cat.No | ABC-TC0903 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Prostate |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Prostate Cancer Cell Lines |
The PC-3 cell line is an essential model in prostate cancer research, allowing in-depth investigation into molecular and biochemical pathways involved in advanced-stage prostate cancer. It is widely used to evaluate responses to chemotherapeutic agents and explore mechanisms of drug resistance. Beyond this, PC-3 cells are commonly employed in virology studies particularly in understanding how viral infections interact with immune-related pathwasy in mammalian cells. Their compatibility with transfection techniques also makes them a reliable host for genetic and molecular biology studies. PC-3 cells are particularly valuable for modeling tumor microenvironments and assessing the therapeutic potential of experimental drugs and treatment strategies.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Saranyutanon S, Deshmukh SK, Dasgupta S, Pai S, Singh S, Singh AP. Cellular and Molecular Progression of Prostate Cancer: Models for Basic and Preclinical Research. Cancers (Basel). 2020;12(9):2651. Published 2020 Sep 17. doi:10.3390/cancers12092651
