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Tumor Cell Lines

PC-3

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The PC-3 was initiated from a bone metastasis of a grade IV prostatic adenocarcinoma from a 62-year-old male Caucasian. The cells exhibit low acid phosphatase and testosterone-5-alpha reductase activities.
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Product Code

PC3; PC.3

Species

Human

Cat.No

ABC-TC0903

Product Category Tumor Cell Lines
Size/Quantity

1 vial

Cell Type

Epithelial

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Prostate

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Human Prostate Cancer Cell Lines

Description

PC-3
PC-3 is a human prostate adenocarcinoma cell line originally derived from a bone metastasis in a 62-year-old Caucasian male with advanced prostate cancer. These cells exhibit epithelial-like morphology with irregular polygonal appearance and adherent culture properties. PC-3 has a highly aneuploid karyotype profile, with chromosomal counts ranging from 58 to 64, falling within the hypertriploid range. The cell line harbors common genetic alterations, including TP53 mutations and PTEN deletion. PC-3 is characterized by the absence of androgen receptor (AR) expression and low prostate-specific antigen (PSA) levels. The cell line is tumorigenic when implanted in SCID mice.
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Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Saranyutanon, S., Deshmukh, S.K., Dasgupta, S., Pai, S., Singh, S. and Singh, A.P., 2020. Cellular and Molecular Progression of Prostate Cancer: Models for Basic and Preclinical Research. Cancers, 12(9), p.2651.

Application

  • PC-3The PC-3 cell line is an essential model in prostate cancer research, allowing in-depth investigation into molecular and biochemical pathways involved in advanced-stage prostate cancer. It is widely used to evaluate responses to chemotherapeutic agents and explore mechanisms of drug resistance. Beyond this, PC-3 cells are commonly employed in virology studies particularly in understanding how viral infections interact with immune-related pathwasy in mammalian cells. Their compatibility with transfection techniques also makes them a reliable host for genetic and molecular biology studies. PC-3 cells are particularly valuable for modeling tumor microenvironments and assessing the therapeutic potential of experimental drugs and treatment strategies.

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