Rabbit Corneal Endothelial Cells

Description

Rabbit Corneal Endothelial Cells (RCECs) are primary cells derived from rabbit corneal endothelium. In vitro, they establish tight junctions and maintain Na⁺/K⁺-ATPase pump activity, essential for corneal hydration and transparency. They proliferate under explant culture or enzymatic isolation and exhibit polygonal morphology that may transition to fibroblastic under TGF‑β/bFGF stimulation. RCECs can undergo endothelial–mesenchymal transition (EMT) in response to growth factors, leading to α‑SMA and vimentin expression—making them valuable for modeling wound healing and endothelial fibrosis. These cells are widely used in ophthalmic research, tissue-engineering, and therapeutic screening.

Application

• For research use only.

• Rabbit Corneal Endothelial Cells are used to model corneal barrier and pump function in vitro, studying Na⁺/K⁺-ATPase and tight junction formation. They are ideal for wound healing assays and epithelial – mesenchymal transition (EMT) research: TGF‑β and bFGF induce fibroblast-like transition with α‑SMA/vimentin expression. Additionally, they serve as testbeds for tissue-engineered graft development and pharmaceutical evaluation of anti-fibrotic or regenerative agents.