Rabbit Corneal Stromal Keratocytes

Description

Rabbit Corneal Stromal Keratocytes are primary cells isolated from the corneal stroma of rabbits. Under serum-free conditions, these cells retain dendritic morphology and express keratan sulfate proteoglycans, which are critical for maintaining extracellular matrix (ECM) organization and corneal transparency. When exposed to TGF‑β1 or FGF‑2, they activate the Rho/ROCK pathway, upregulate α‑SMA, and downregulate ECM components like keratocan and lumican, thereby differentiating into myofibroblasts. These phenotypic transitions make them a valuable in vitro model for studying corneal fibrosis, wound healing, and drug screening applications in ocular research.

Application

• For research use only.

• Rabbit Corneal Stromal Keratocytes are widely used in models of corneal wound healing to study keratocyte apoptosis, ECM remodeling, and proliferation. They also serve in fibrosis research through TGF‑β-induced myofibroblast differentiation, enabling evaluation of anti-scarring or anti-fibrotic compounds. Additionally, their behavior on nanoscale topographies supports studies in cell-material interaction and regenerative biomaterials.