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Rabbit Corneal Stromal Keratocytes

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    1

  • 77
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Home | Primary Cells | Animal Primary Cells | Rabbit Corneal Stromal Keratocytes
Species

Rabbit
Cat.No

ABC-TC131W
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Keratocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Cornea
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Corneal Cell

Description

Rabbit Corneal Stromal Keratocytes are primary cells isolated from the corneal stroma of rabbits. Under serum-free conditions, these cells retain dendritic morphology and express keratan sulfate proteoglycans, which are critical for maintaining extracellular matrix (ECM) organization and corneal transparency. When exposed to TGF‑β1 or FGF‑2, they activate the Rho/ROCK pathway, upregulate α‑SMA, and downregulate ECM components like keratocan and lumican, thereby differentiating into myofibroblasts. These phenotypic transitions make them a valuable in vitro model for studying corneal fibrosis, wound healing, and drug screening applications in ocular research.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only.

  • Rabbit Corneal Stromal Keratocytes are widely used in models of corneal wound healing to study keratocyte apoptosis, ECM remodeling, and proliferation. They also serve in fibrosis research through TGF‑β-induced myofibroblast differentiation, enabling evaluation of anti-scarring or anti-fibrotic compounds. Additionally, their behavior on nanoscale topographies supports studies in cell-material interaction and regenerative biomaterials.

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