Rat Neurons-Hippocampal

Description

Rat Hippocampal Neurons are primary neuronal cells isolated from the hippocampus of rats – a brain region essential for learning and spatial memory. These cells typically cryopreserved at the earliest passage and exhibit neuronal-like morphology with adherent growth properties. In vitro, they exhibit polarized processes with clearly defined axons and dendrites, forming functional synaptic networks. Functionally, they regulate synaptic plasticity through mechanisms like long-term potentiation and have been implicated in Alzheimer’s disease pathogenesis, particularly via amyloid-β oligomer-induced upregulation of TLR4. These cells are capable of releasing high levels of neurotransmitter, including GABA and glutamic acid. Due to their terminally differentiated state, repeated freeze-thaw cycles should be avoided.

Application

• Rat hippocampal neurons provide a robust in vitro model for neuroscience research. They provide a valuable platform for studying neurophysiology, neural plasticity, and memory storage – areas critical for understanding the mechanisms behind learning navigation, and cognitive function. These neurons are also instrumental in investigating neurological disorders such as Alzheimer’s disease, encephalitis, epilepsy, and amnesia. By investigating hippocampal neurons, researchers gain valuable insights into brain physiology, disease mechanisms, and pathology, supporting the development of novel therapeutic strategies and clinical interventions.