Rat Peripheral Blood Mononuclear Cells

Description

Rat PBMCs are isolated from rat peripheral blood by density gradient centrifugation, mainly including lymphocytes (T cells, B cells, NK cells) and monocytes, essential for preclinical immunology and toxicology research. The core functions of rPBMCs involve immune regulation: T cells dominate adaptive immune responses, B cells mediate humoral immunity, NK cells perform natural killing functions, and monocytes can differentiate into macrophages or dendritic cells to participate in antigen presentation. These cells maintain native morphology and express conserved immune markers (e.g., CD3, CD45RA, CD161), enabling studies in immune activation, inflammation, and autoimmune disease mechanisms. Rat PBMCs are particularly valuable for translational research due to their physiological similarity to human immune responses.