Recombinant Human IGF1 Protein

Description

Insulin-like Growth Factors (IGF1), also known as Mechano Growth Factor, somatomedin-C, IGF-I and IGF-1, is a secreted protein that belongs to the insulin family. The IGF1 constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. IGF1 expression is regulated by GH and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development. IGF1 may be a physiological regulator of transport and glycogen synthesis in osteoblasts. IGF1 stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells. It regulates glycogen and DNA synthesis and enhances glucose uptake at lower concentrations than insulin. Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness, and mental retardation.