Recombinant Mouse TGF beta 1 Protein (Latent, His Tag)

Description

TGF beta 1 (TGF-β1) is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis factor-alpha and various interleukins. It can also decrease the expression levels of cytokine receptors. Meanwhile, TGF beta 1 also increases the expression of certain cytokines in T cells and promotes their proliferation, particularly if the cells are immature. TGF beta 1 also inhibits proliferation and stimulates apoptosis of B cells by controlling antibody expression on immature and mature B cells. In myeloid cells, TGF beta 1 can exert context-dependent effects, including inhibition or stimulation of proliferation depending on cellular state and microenvironment.