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| Product Code | VCAP; Vcap; Vertebral Cancer of the Prostate |
| Species | Human |
| Cat.No | ABC-TC1272 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Prostate |
| Disease | Prostate Cancer |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Prostate Cancer Cell Lines |
VCaP is a prostate adenocarcinoma cell line that was originally isolated from the metastatic tumor to the vertebrae of a 59-year-old caucasian male patient with hormone-refractory prostate cancer. VCaP exhibits epithelial-like morphology and adherent culture properties. This cell highly express prostate specific antigen (PSA)prostatic acid phosphatase (PAP), cytokeratin-18 and the wild type androgen receptor. It is sensitive to androgen treatment. VCaP is tumorigenic, it capable to form a tumor in nude and SCID mice. Its concurring a lager proportion of genomic rearrangements along the q arm of chromosome 5 which indicate to chromothripsis.
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Saranyutanon, S., Deshmukh, S.K., Dasgupta, S., Pai, S., Singh, S. and Singh, A.P., 2020. Cellular and Molecular Progression of Prostate Cancer: Models for Basic and Preclinical Research. Cancers, 12(9), p.2651.
The VCaP cell line serves as a valuable cell-based model for human prostate cancer, enhancing the toolkit for studying the mechanisms driving prostate cancer progression and metastasis. Its application extends to investigating crucial factors like the human retrovirus XMRV (xenotropic murine leukemia virus-related virus) within prostate carcinoma. The cells are tumourigenic in SCID mice. With its expression of unaltered androgen receptor and ability to proliferate independently of androgens, the VCaP cell line is exceptionally suited for investigating the intricate dynamics of castration-resistant prostate cancer.
