For research use only
| Cat No. | ABL-TC0743 |
| Product Type | Human Lung Cell Lines |
| Cell Type | Fibroblast |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Lung |
| Disease | Normal |
| Product Code | WI-38, WI 38, WI38 Cells, Human Lung Fibroblast Cell Line WI-38, Diploid Fibroblast Cells |
WI-38 ,Human fibroblast-like lung cell line; normal diploid fibroblast with limited lifespan, distributed around 30 PDL for research applications.
WI‑38 is a human diploid fibroblast cell line derived in 1962 from the lung tissue of a healthy 3‑month‑gestation female fetus. This adherent cell line exhibit fibroblast-like, spindle-shaped morphology and demonstrates a doubling time of approximately 24 hours under standard culture conditions. Karyotypic analysis confirms a normal diploid complement (46, XX). It played a landmark role as the first human diploid strain approved for vaccine production—supporting generation of rubella, poliovirus, hepatitis A, adenovirus, rabies, and varicella vaccines—thus significantly contributing to public health. WI‑38 also serves as a reference model for replicative senescence, cellular aging research, genome stability, and fibroblast differentiation dynamics including reversible myofibroblast/lipofibroblast switching.
| Product Code | WI-38, WI 38, WI38 Cells, Human Lung Fibroblast Cell Line WI-38, Diploid Fibroblast Cells |
| Species | Human |
| Cat.No | ABL-TC0743 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Fibroblast |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Lung |
| Disease | Normal |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Lung Cell Lines |
The WI-38 cell line has played a pioneering role in vaccine development, serving as the first human cell strain used in production of licensed viral vaccines. It has contribute significantly to the development and manufacturing of vaccines against a spectrum of diseases such as poliomyelitis, measles, mumps, rubella, varicella (chicken pox), herpes zoster, adenovirus, rabies, and Hepatitis A. Moreover, it continues to be a valuable resource for virus propagation, vaccine quality control, and virucide testing, underscores its enduring value in virology and public health research. Beyond its vaccine production utility, WI-38 serves as an reliable transfection host and a model system for studying human cellular aging, senescence, and genome stability, broadening its relevance beyond vaccine applications.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
