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| Product Code | Wi-38; WI 38; WI38 |
| Species | Human |
| Cat.No | ABL-TC0743 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Fibroblast |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Lung |
| Disease | Normal |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Lung Cell Lines |
WI-38 is a human fibroblast cell line originally derived from the lung tissue of a 3-month-gestation female fetus of European descent without associated disease. This adherent cell line exhibit fibroblast-like morphology and demonstrates a doubling time of approximately 24 hours under standard culture conditions. Karyotypic analysis confirms a normal diploid complement (46,XX). As the first human diploid cell line approved for vaccine production, it has been instrumental in biomedical research and biomanufacturing. Its susceptibility to a broad range of human viruses, coupled with its genetic stability, has made it instrumental in the production of vaccines against diseases such as rubella, rabies, and adenovirus.
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The WI-38 cell line has played a pioneering role in vaccine development , serving as the first human cell strain used in production of licensed viral vaccines. It has contribute significantly to the development and manufacturing of vaccines against a spectrum of diseases such as poliomyelitis, measles, mumps, rubella, varicella (chicken pox), herpes zoster, adenovirus, rabies, and Hepatitis A. Moreover, it continues to be a valuable resource for virus propagation, vaccine quality control, and virucide testing, underscores its enduring value in virology and public health research. Beyond its vaccine production utility, WI-38 serves as an reliable transfection host and a model system for studying human cellular aging, senescence, and genome stability, broadening its relevance beyond vaccine applications.
