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Tumor Cell Lines

WM-266-4

  • BSL

    1

  • 254
Human melanoma. Derived from a metastasis of the same parent as WM-115.
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Product Code

WM-266-4; WM 266-4; WM-2664; WM2664; WM 2664; WM266; WM-266-mel; WM266mel; WC00097

Species

Human

Cat.No

ABC-TC1292

Product Category Tumor Cell Lines
Size/Quantity

1 vial

Cell Type

Epithelial

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Human Melanoma Cell Lines

Description

WM-266-4
WM-266-4 is a human malignant melanoma cell line that was originally isolated from the skin metastatic site of a 58-year-old female patient with metastatic melanoma. WM-266-4 exhibits epithelial-like morphology and adherent growth characteristics. It is hypertriploid, harboring a V600D mutation in the BRAF gene and homozygous deletion of PTEN. N-RAS, c-KIT ,and CDK4 genes are wild-type. WM-266-4 is tumorigenic.
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Citation

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Application

  • The WM-266-4 cell line is crucial in immuno-oncology for uncovering signaling pathways involved in tumor immune escape. Researchers use it to study IFN-γ stimulation and its impact on immune checkpoint inhibitor expression in melanoma cells. Additionally, WM-266-4 helps identify and investigate novel therapeutic targets for melanoma, shedding light on mechanisms that may induce antiproliferative and proapoptotic effects. This cell line is instrumental in advancing pharmacological treatments for melanoma, contributing to the development of new and more effective therapies.

Frequently Asked Questions

  • What are WM-266-4 cells?

    WM-266-4 cells are a metastatic human melanoma cell line that derived from a metastatic site of a malignant melanoma.

  • What culture medium is recommended for WM-266-4 cells?

    The culture medium recommended for WM-266-4 cells is composed of High Glucose 1640 supplemented with appropriate additives to support optimal cell growth and maintenance, adding 10% FBS.

  • What are the applications of WM-266-4 cell line?

    The applications include cellular assay, genetic studies, xenograft production, drug testing

Inquiring WM-266-4

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