For research use only
| Cat No. | ABC-TC1292 |
| Product Type | Human Melanoma Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Product Code | WM-266-4; WM 266-4; WM-2664; WM2664; WM 2664; WM266; WM-266-mel; WM266mel; WC00097 |
Human WM-266-4 melanoma cells with BRAF V600D mutation and PTEN deletion, used for metastatic melanoma and tumorigenesis research.
WM-266-4 is a human malignant melanoma cell line derived from a skin metastasis of a 58-year-old female patient with stage III (Clark level) melanoma. These adherent cells exhibit an epithelial-like, small, flat, mesenchymal morphology. WM-266-4 harbors the oncogenic BRAF V600D mutation, driving constitutive MAPK pathway activation, and displays PTEN loss of function due to hemizygous deletion. The cell line is wild-type for N-RAS, c-KIT, and CDK4, providing a distinct model to study BRAF-driven melanoma. WM-266-4 cells are tumorigenic and form xenografts in immunodeficient mice, supporting their use in melanoma progression and targeted therapy research. Their stable growth, defined genetic background, and reproducible tumorigenicity make them valuable for preclinical drug testing and mechanistic studies of metastatic melanoma.
| Product Code | WM-266-4; WM 266-4; WM-2664; WM2664; WM 2664; WM266; WM-266-mel; WM266mel; WC00097 |
| Species | Human |
| Cat.No | ABC-TC1292 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Melanoma Cell Lines |
The WM-266-4 cell line is crucial in immuno-oncology for uncovering signaling pathways involved in tumor immune escape. Researchers use it to study IFN-γ stimulation and its impact on immune checkpoint inhibitor expression in melanoma cells. Additionally, WM-266-4 helps identify and investigate novel therapeutic targets for melanoma, shedding light on mechanisms that may induce antiproliferative and proapoptotic effects. This cell line is instrumental in advancing pharmacological treatments for melanoma, contributing to the development of new and more effective therapies.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
WM-266-4 cells are a metastatic human melanoma cell line that derived from a metastatic site of a malignant melanoma.
The culture medium recommended for WM-266-4 cells is composed of High Glucose 1640 supplemented with appropriate additives to support optimal cell growth and maintenance, adding 10% FBS.
The applications include cellular assay, genetic studies, xenograft production, drug testing
