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Xpress™ Cyno GPC3 Over-expressing Cell Line (CHOK1)

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Xpress™ Cyno GPC3 Over-expressing Cell Line (CHOK1)
Species

Crab-eating macaque
Cat.No

ABC-X0416C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Ovary
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

CHOK1

Description

Cyno GPC3 CHOK1 Overexpression Cell Line is a genetically engineered model derived from selected Chinese hamster ovary (CHOK1) parental cell line based on customers’ requirement. Cyno GPC3 CHOK1 overexpression cell line is generated by stable integration of exogenous cynomolgus monkey GPC3 into CHOK1 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
GPC3 (Glypican 3) is a membrane-bound heparan sulfate proteoglycan involved in Wnt signaling and cell proliferation. It is overexpressed in hepatocellular carcinoma and used as a biomarker and therapeutic target in liver cancers. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This cynomolgus model aids in cross-species validation of GPC3-targeted therapies, including antibody-drug conjugates and CAR-T cell products, facilitating translational safety studies in non-human primates.

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