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Xpress™ Human AKR1B1 Over-expressing Cell Line (NCI-H1975)

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  • 70
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Xpress™ Human AKR1B1 Over-expressing Cell Line (NCI-H1975)
Species

Human
Cat.No

ABC-X0040C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lung
Disease

Carcinoma
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

NCI-H1975

Description

Xpress™ Human AKR1B1 Over-expressing Cell Line (NCI-H1975) is a genetically modified model derived from the NCI-H1975 lung adenocarcinoma cell line based on customers’ requirement. This overexpression cell line is constructed via stable lentiviral-mediated transduction of the human AKR1B1 gene.
Target
AKR1B1 (Aldo-Keto Reductase Family 1 Member B1) plays a critical role in detoxification of aldehydes and has been implicated in diabetic complications, inflammation, and cancer. Overexpression of AKR1B1 enhances tumor cell proliferation, epithelial plasticity, and metabolic reprogramming. AcceGen enables generation of functionally validated overexpression models for drug discovery and biomarker research. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The Xpress™ Human AKR1B1 Over-expressing Cell Line (NCI-H1975) is a valuable model for studying AKR1B1-related metabolic pathways, tumor cell plasticity, and chemoresistance. It is well-suited for compound screening, mechanism-of-action studies, and AKR1B1-targeted therapeutic development.

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