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Transfected Stable Cell Lines

Xpress™ Human AKR1B1 Over-expressing Cell Line (NCI-H1975)

  • For research use only

Cat No.

ABC-X0040C

Product Type

Overexpression Stable Cell Lines

Cell Type

Epithelial

Species

Human

Host Cell

NCI-H1975

Source Organ

Lung

Disease

Carcinoma

Storage

Liquid Nitrogen

The human AKR1B1 overexpression cell line (NCI-H1975) provides an ideal preclinical model for targeted drug discovery and biomarker research.

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Description

Xpress™ Human AKR1B1 Over-expressing Cell Line (NCI-H1975) is a genetically modified model derived from the NCI-H1975 lung adenocarcinoma cell line based on customers’ requirement. This overexpression cell line is constructed via stable lentiviral-mediated transduction of the human AKR1B1 gene.
Target
AKR1B1 (Aldo-Keto Reductase Family 1 Member B1) plays a critical role in detoxification of aldehydes and has been implicated in diabetic complications, inflammation, and cancer. Overexpression of AKR1B1 enhances tumor cell proliferation, epithelial plasticity, and metabolic reprogramming. AcceGen enables generation of functionally validated overexpression models for drug discovery and biomarker research. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human

Cat.No

ABC-X0040C

Product Category

Transfected Stable Cell Lines

Size/Quantity

1 vial

Cell Type

Epithelial

Growth Mode

Adherent

Shipping Info

Dry Ice

Growth Conditions

37 °C, 5% CO₂

Source Organ

Lung

Disease

Carcinoma

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Overexpression Stable Cell Lines

Host Cell

NCI-H1975

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • The Xpress™ Human AKR1B1 Over-expressing Cell Line (NCI-H1975) is a valuable model for studying AKR1B1-related metabolic pathways, tumor cell plasticity, and chemoresistance. It is well-suited for compound screening, mechanism-of-action studies, and AKR1B1-targeted therapeutic development.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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