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Xpress™ Human B7H4 Over-expressing Cell Line (BAF3)

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Xpress™ Human B7H4 Over-expressing Cell Line (BAF3)
Species

Human
Cat.No

ABC-X0154C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Xpress™ Human B7H4 over-expressing cell line (BAF3) is a genetically engineered model derived from selected murine pro-B cell line BAF3 based on customers’ requirement. B7H4 BAF3 overexpression cell line is generated by stable integration of exogenous human B7H4 into BAF3 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
The B7H4 gene encodes an inhibitory immune checkpoint molecule of the B7 family that negatively regulates T cell immunity. Its overexpression in multiple solid tumors is associated with immune evasion and poor clinical outcomes, making B7H4 a potential target for immunotherapy. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The B7H4 BAF3 Overexpression Cell Line is ideal for studying immune checkpoint blockade, tumor immune suppression, and screening B7H4-targeted monoclonal antibodies or bispecifics in hematopoietic contexts.

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