For research use only
| Cat No. | ABC-X0274C |
| Product Type | Overexpression Stable Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Host Cell | 293T |
| Source Organ | Kidney |
| Disease | Normal |
| Storage | Liquid Nitrogen |
293T cells engineered to stably express human CCR2a isoform, ideal for chemokine signaling pathway research in inflammation and immune cell migration.
Xpress™ Human CCR2a Overexpression Cell Line is a genetically engineered model derived from selected human embryonic kidney (293T) parental cell line based on customers’ requirement. CCR2a 293T overexpression cell line is generated by stable integration of exogenous human CCR2a into 293T host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
The CCR2a gene encodes a chemokine receptor variant involved in monocyte and macrophage recruitment to inflammatory sites. It binds CCL2 and other chemokines, mediating immune responses and contributing to diseases such as multiple sclerosis and cancer. The protein resides in the plasma membrane and activates G protein-dependent signaling cascades. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.
| Species | Human |
| Cat.No | ABC-X0274C |
| Product Category | Transfected Stable Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 °C, 5% CO2 |
| Source Organ | Kidney |
| Disease | Normal |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Overexpression Stable Cell Lines |
| Host Cell | 293T |
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
The CCR2a 293T Overexpression Cell Line serves as a powerful tool to investigate CCR2a-mediated chemokine signaling and leukocyte trafficking. This model supports drug discovery targeting chronic inflammation and tumor microenvironment modulation. It is utilized for evaluating antagonists and therapeutic antibodies against CCR2a.