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Xpress™ Human CD228 Over-expressing Cell Line (A549)

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Xpress™ Human CD228 Over-expressing Cell Line (A549)
Species

Human
Cat.No

ABC-X0142C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lung
Disease

Lung Cancer
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

A549

Description

Xpress™ Human CD228 over-expressing cell line (A549) is a genetically engineered model derived from selected human lung adenocarcinoma A549 parental cell line. CD228 A549 overexpression cell line is generated by stable integration of exogenous human CD228 (also known as MUC18 or MCAM) into A549 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
The CD228 gene encodes a cell surface glycoprotein belonging to the immunoglobulin superfamily, involved in cell adhesion, signal transduction, and tumor progression. CD228 expression is elevated in various cancers, including melanoma, prostate cancer, and non-small cell lung cancer (NSCLC), where it promotes cell migration, invasion, and angiogenesis. It activates pathways such as PI3K/AKT and MAPK, contributing to metastasis and therapy resistance. The protein localizes predominantly to the plasma membrane and is a potential target for antibody-based therapies in oncology.

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Application

  • For research use only

  • The CD228 A549 Overexpression Cell Line serves as a powerful tool to investigate CD228-mediated oncogenic pathways and evaluate therapeutic strategies in lung cancer. This model supports mechanistic studies of tumor cell adhesion, migration, and immune evasion in the tumor microenvironment. It is suitable for high-throughput screening of CD228-targeted treatments, including monoclonal antibodies and immune checkpoint modulators.

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