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Xpress™ Human CD39 Over-expressing Cell Line (MC38)

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Xpress™ Human CD39 Over-expressing Cell Line (MC38)
Species

Human
Cat.No

ABC-X0138C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial-like
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Colon
Disease

Colon Adenocarcinoma
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

MC38

Description

Xpress™ Human CD39 over-expressing cell line (MC38) is a genetically engineered model derived from selected murine MC38 parental cell line based on customers’ requirement. Human CD39 overexpression cell line is generated by stable integration of exogenous human CD39 gene into MC38 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
CD39 is an immunosuppressive enzyme that acts upstream of CD73 in the adenosinergic pathway, promoting tumor growth and immune evasion. It is considered a potential target for reversing T cell exhaustion and enhancing antitumor immunity in solid tumors. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The Xpress™ Human CD39 over-expressing cell line (MC38) supports detailed mechanistic studies on purinergic signaling and immune modulation. It is ideal for preclinical evaluation of CD39-blocking agents and combination immunotherapies.

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