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Transfected Stable Cell Lines

Xpress™ Human FGL1 Over-expressing Cell Line (MC38)

  • For research use only

Cat No.

ABC-X0226C
Product Type

Overexpression Stable Cell Lines
Cell Type

Epithelial-like
Species

Human
Host Cell

MC38
Source Organ

Colon
Disease

Colon Adenocarcinoma
Storage

Liquid Nitrogen

The Xpress™ Human FGL1 Overexpression Cell Line (MC38) enables immune evasion research and development of LAG-3 pathway-targeted cancer therapies.

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  • Xpress™ Human FGL1 Over-expressing Cell Line (MC38)
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Xpress™ Human FGL1 Over-expressing Cell Line (MC38)

Description

The FGL1 MC38 Overexpression Cell Line is a genetically engineered model derived from murine colorectal cancer MC38 cells based on customers’ requirement. FGL1 MC38 overexpression cell line is generated by stable integration of exogenous human FGL1 into MC38 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
FGL1 (Fibrinogen-like protein 1) acts as a major ligand of LAG-3 and contributes to immune evasion in cancers. It is a promising target in immunotherapy due to its suppressive effect on T cell function. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0226C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial-like
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Colon
Disease

Colon Adenocarcinoma
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

MC38
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Application

  • The FGL1 MC38 Overexpression Cell Line is ideal for evaluating immune checkpoint inhibitors and understanding tumor immune escape mechanisms in preclinical murine models.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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