For research use only
| Cat No. | ABC-X0372C |
| Product Type | Overexpression Stable Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Host Cell | CHOK1 |
| Source Organ | Ovary |
| Disease | Normal |
| Storage | Liquid Nitrogen |
CHOK1 cells engineered to express human IL2RB, suitable for modeling IL-2/IL-15 receptor signaling pathways and studying T cell development or expansion.
IL2RB CHOK1 Overexpression Cell Line is a genetically engineered model derived from selected Chinese hamster ovary (CHOK1) parental cell line based on customers’ requirement. IL2RB CHOK1 overexpression cell line is generated by stable integration of exogenous human IL2RB into CHOK1 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
The IL2RB gene encodes the beta subunit of the interleukin-2 receptor, which is essential for high-affinity IL-2 signaling in T cells and NK cells. IL2RB forms a complex with IL2RA and IL2RG to mediate immune activation, proliferation, and survival. Dysregulation of IL2RB expression and function has been implicated in immune disorders and cancer immunotherapy. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.
| Species | Human |
| Cat.No | ABC-X0372C |
| Product Category | Transfected Stable Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 °C, 5% CO2 |
| Source Organ | Ovary |
| Disease | Normal |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Overexpression Stable Cell Lines |
| Host Cell | CHOK1 |
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
The IL2RB CHOK1 Overexpression Cell Line serves as a powerful tool to investigate IL-2 receptor signaling and cytokine-driven immune responses. This model enables mechanistic studies of receptor-ligand binding, downstream STAT signaling, and therapeutic modulation. It is widely used in screening IL2/IL2R-targeted biologics and understanding T/NK cell activation dynamics.