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Xpress™ Human PVRL4 Over-expressing Cell Line (B16/F10)

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Xpress™ Human PVRL4 Over-expressing Cell Line (B16/F10)
Species

Human
Cat.No

ABC-X0141C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial-like
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Skin
Disease

Melanoma
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

B16/F10

Description

Xpress™ Human PVRL4 over-expressing cell line (B16/F10) is a genetically engineered model derived from selected murine B16/F10 parental cell line. Human PVRL4 overexpression cell line is generated by stable integration of exogenous human PVRL4 gene into B16/F10 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
PVRL4 (Nectin-4) is a cell adhesion molecule involved in epithelial tissue integrity and tumor progression. It is overexpressed in various cancers, including breast, bladder, and lung cancers, and serves as a target for antibody-drug conjugates such as enfortumab vedotin.

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Application

  • For research use only

  • The Xpress™ Human PVRL4 over-expressing cell line (B16/F10) enables the exploration of tumor cell adhesion, metastasis, and PVRL4-mediated immune modulation. It is suitable for preclinical studies of PVRL4-targeted immunotherapies and ADC efficacy evaluation.

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