For research use only
| Cat No. | ABC-X0129C |
| Product Type | Overexpression Stable Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Host Cell | CHOK1 |
| Source Organ | Ovary |
| Disease | Normal |
| Storage | Liquid Nitrogen |
The Human PVRL4 Overexpression Cell Line (CHOK1) provides an ideal platform for tumor antigen validation and targeted therapy, aiding cancer research.
Xpress™ Human PVRL4 over-expressing cell line (CHOK1) is a CHOK1-based model engineered to stably express the human PVRL4 gene, also known as nectin-4, using lentiviral gene delivery for consistent and robust surface presentation.
Target
PVRL4 (Nectin-4) is a cell adhesion molecule overexpressed in multiple cancers, including breast, bladder, and lung cancers. It has been identified as a tumor-associated antigen and is the target of the FDA-approved antibody-drug conjugate enfortumab vedotin.
| Species | Human |
| Cat.No | ABC-X0129C |
| Product Category | Transfected Stable Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 °C, 5% CO₂ |
| Source Organ | Ovary |
| Disease | Normal |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Overexpression Stable Cell Lines |
| Host Cell | CHOK1 |
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
The Xpress™ Human PVRL4 over-expressing cell line (CHOK1) is an ideal system for tumor antigen validation, antibody binding and cytotoxicity assays, and evaluation of PVRL4-targeted therapeutics in oncology research.