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Xpress™ Human RANKL Over-expressing Cell Line (HEK293T)

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Xpress™ Human RANKL Over-expressing Cell Line (HEK293T)
Species

Human
Cat.No

ABC-X0145C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Kidney
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

HEK293T

Description

Xpress™ Human RANKL over-expressing cell line (HEK293T) is a genetically engineered model derived from selected human embryonic kidney 293T parental cell line based on customers’ requirement. RANKL HEK293T overexpression cell line is generated by stable integration of exogenous human RANKL (TNFSF11) into HEK293T host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
The RANKL gene encodes a key member of the tumor necrosis factor (TNF) superfamily that regulates osteoclast differentiation, bone resorption, and immune responses. Overexpression of RANKL contributes to osteolytic lesions in cancers such as breast and prostate cancer, and it plays a crucial role in the tumor-bone microenvironment. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The RANKL HEK293T Overexpression Cell Line is ideal for studying bone metastasis, osteoclast activation, and tumor–bone interactions. It supports screening of RANKL-targeting agents such as denosumab in bone-related oncologic and inflammatory research.

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