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Xpress™ Mouse SIRPA Over-expressing Cell Line (CHOK1)

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Xpress™ Mouse SIRPA Over-expressing Cell Line (CHOK1)
Species

Mouse
Cat.No

ABC-X0131C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Ovary
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

CHOK1

Description

Xpress™ Mouse SIRPA over-expressing cell line (CHOK1) is a genetically engineered model derived from selected CHOK1 parental cell line based on customers’ requirement. Mouse SIRPA overexpression cell line is generated by stable integration of exogenous mouse SIRPA gene into CHOK1 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
SIRPA (Signal Regulatory Protein Alpha) is a transmembrane glycoprotein that functions as an inhibitory receptor regulating immune cell activation. It is predominantly expressed on myeloid cells and mediates its effects via interaction with CD47, delivering a “don’t eat me” signal to macrophages. The SIRPA-CD47 axis is a critical immune checkpoint in tumor immune evasion and is widely studied in the context of cancer immunotherapy. The target protein localizes to the plasma membrane and is involved in ITIM-mediated signaling. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

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Application

  • For research use only

  • The Xpress™ Mouse SIRPA over-expressing cell line (CHOK1) serves as a valuable tool for investigating the molecular mechanisms of SIRPA-CD47 signaling in immune suppression and tumor immunology. It enables functional assays for ligand-receptor binding, antibody screening, and checkpoint blockade validation. This model supports the development of anti-CD47/SIRPA therapeutic strategies, including monoclonal antibodies and fusion proteins, and is applicable in high-throughput screening platforms.

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