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Xpress™ Rat LAG3 Over-expressing Cell Line (CHOK1)

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Xpress™ Rat LAG3 Over-expressing Cell Line (CHOK1)
Species

Rat
Cat.No

ABC-X0356C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Ovary
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

CHOK1

Description

LAG3 CHOK1 Overexpression Cell Line is a genetically engineered model derived from selected Chinese hamster ovary (CHOK1) parental cell line based on customers’ requirement. LAG3 CHOK1 overexpression cell line is generated by stable integration of exogenous rat LAG3 into CHOK1 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
The LAG3 gene encodes a transmembrane protein expressed on activated T cells and natural killer cells, functioning as an immune checkpoint regulator. It negatively regulates T cell activation and proliferation and plays a key role in maintaining immune tolerance. LAG3 is a promising immunotherapeutic target in cancer and chronic infections due to its suppressive effects on antitumor immune responses. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The LAG3 CHOK1 Overexpression Cell Line serves as a powerful tool to investigate LAG3-mediated immunosuppression and checkpoint blockade strategies. This model enables mechanistic studies of T cell exhaustion and immune modulation in tumor and inflammatory microenvironments. It is utilized for high-throughput screening of LAG3-targeted therapeutics, including monoclonal antibodies and fusion proteins.

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